string fileName = Server.MapPath("~/DownFiles/Data.Txt");

            FileInfo file = new FileInfo(fileName);

            using (FileStream fileStream = file.Open(FileMode.Open))

            {

                StreamReader streamReader = new StreamReader(fileStream);

                while (!streamReader.EndOfStream)

                {

                    string line = streamReader.ReadLine();

                    string[] strs = line.Split(',');

                    //DoYourInsert()

                }

            }