$db=new mysqli("localhost","admin","admin","ssq");
$db->query("truncate table hmk");
$info = array(1, 2, 3,4,5,6);//$info是中间生成的的组合数组.
foreach ($info as $skey=>$value){
     //echo 'my array is underline:'.$key."=>".$value."</br>" ;
     $query="insert into hmk(l1,l2,l3,l4,l5,l6) values($values)";  
     $result=$db->query($query) ;
} 
if (result)
echo "good luck"           ;
else echo "sorry"    ;
$db->close();

$a  = range(1, 33);
$ar = combination($a, 6);

//求组合高效率的10移动法
function combination($numArr,$combineLen) {
  $numCt    = count($numArr);
  if($combineLen > $numCt) return;
  $bin    = str_pad('',$combineLen,'1');
  $bin    = str_pad($bin,$numCt,'0',STR_PAD_RIGHT);    
  $find    = $bin;
  $rs[]    = implode(' ',array_slice($numArr,0,$combineLen));
  $j        = 1;
  while(strrev($find) != $bin) {
    $k = explode('10',$find,2);
    $find = $find{0} === '0' ? strrev($k[0]).'01'.$k[1] : $k[0].'01'.$k[1];
    for($i=0;$i<$numCt;$i++) $rs[$j] .=  $find[$i] ?  $numArr[$i] . " " : '';
    $j++;
  }
  return $rs;
}

$fp = fopen('数据.txt', 'r');
while( !feof($fp) ){
    $line = trim( fget($fp) );
    $sqlvalue .= '('. substr($line, 1, -1) . '),';
}
$sql = "insert into hmk(l1,l2,l3,l4,l5,l6) values ";
$sql = $sql . substr($sqlvalue, -1, 1); // 去掉末尾的 ,

$db = new mysqli("localhost","admin","admin","ssq");
$result = $db->query($sql);
if( ! $result ){
    echo $db->error();
    var_dump($sql);
}

------解决方案--------------------
每次查询只插入一条记录效率太低了，可以批量插入，比如每次50000条：

PHP code
$data = array(array(1,2,3,4,5,6), array(1,2,3,4,57)); //先生成这样的data数组，每个元素是一组号码的数组
$idx = 0;
while($idx < count($data) - 1)) {
    $ar = array();
    if ($idx + 50000 < count($data)) $ar = array_slice($data, $idx, 50000);
    else $ar = array_slice($data, $idx);
    $sql = 'INSERT INTO htm(l1,l2,l3,l4,l5,l6) VALUES ';
    $ar_values = array();
    foreach($ar as $v) $ar_values[] = '('.join(',', $v).')';
    $sql .= join(',', $ar_values);
    $result = $db->query($sql);
    $idx += 50000;
}
$db->close();

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